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Est. 2005 · Eugene, OR

amitriptyline — MetaHistoryBook

amitriptyline

medicine used to treat cyclic vomiting syndrome (CVS), depression and a variety of pain syndromes

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Details

Instance of: type of chemical entity
Subclass of: dibenzocycloheptene
Has parts: carbon
active ingredient in: Elavil
canonical SMILES: CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
chemical formula: C₂₀H₂₃N
defined daily dose: 75, 75
has use: medication
legal status (medicine): boxed warning
LiverTox likelihood score: LiverTox toxicity likelihood category B
mass: 277.183
medical condition treated: pain, neurotic disorder, fibromyalgia, insomnia, migraine
physically interacts with: 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine (serotonin) receptor 7, Histamine receptor H1, Potassium inwardly-rectifying channel, subfamily J, member 6, Potassium inwardly-rectifying channel, subfamily J, member 5, Cholinergic receptor muscarinic 1, Cholinergic receptor muscarinic 2, Cholinergic receptor muscarinic 3, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Solute carrier family 6 member 2, solute carrier family 6 member 4
pregnancy category: Australian pregnancy category C, US pregnancy category C
route of administration: oral administration, intramuscular injection, intravenous infusion and defusion
significant drug interaction: isocarboxazid, phenelzine, procarbazine, (±)-deprenyl, tranylcypromine, loxapine, trimipramine, nabumetone, naproxen, celecoxib, Diclofenac, piroxicam
subject has role: selective serotonin reuptake inhibitor, adrenergic uptake inhibitors, non-opioid analgesic, tricyclic antidepressant, WHO essential medicine
World Health Organisation international non-proprietary name: amitriptyline

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