paclitaxel

Details

Instance of

type of chemical entity

Subclass of

taxoids

Part of

paclitaxel biosynthetic process, 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity

active ingredient in

Abraxane, Paxene, paclitaxel polyglutamate

canonical SMILES

CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

chemical formula

C₄₇H₅₁NO₁₄

found in taxon

Taxus brevifolia, Taxus canadensis, Corylus avellana, Pestalotiopsis guepinii, Pestalotiopsis microspora, Afrocarpus gracilior, Seimatoantlerium tequiensis, Taxomyces andreanae, Taxus floridana, Taxus sumatrana, Torreya californica, Trichothecium

has characteristic

natural product

has use

medication, biological research, chemical probe

isomeric SMILES

CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

legal status (medicine)

boxed warning

LiverTox likelihood score

LiverTox toxicity likelihood category D

manufacturer

Pfizer

mass

853.331

medical condition treated

lung benign neoplasm, breast cancer, ovarian cancer, Kaposi's sarcoma, head and neck squamous cell carcinoma, melanoma, pancreatic adenocarcinoma, non-small-cell lung carcinoma, invasive ductal carcinoma, gastric adenocarcinoma, squamous cell carcinoma of the lung, metastatic melanoma

physically interacts with

nuclear receptor subfamily 1 group I member 2, Toll-like receptor 4, Tubulin beta class I

pregnancy category

US pregnancy category D

significant drug interaction

trimethoprim, crizotinib, idelalisib, amiodarone, fosphenytoin, phenytoin

stereoisomer of

(2R,3R)-3-(Benzoylamino)-2-hydroxy-3-phenylpropionic acid 1,7beta-dihydroxy-2alpha-(benzoyloxy)-4,10beta-diacetoxy-9-oxo-5beta,20-epoxytaxa-11-ene-13alpha-yl ester, nsc-lsc-1, 7-epitaxol

stylized name

PACLitaxel

subject has role

immunologic adjuvant, tubulin modulators, phytogenic antineoplastic agents, female reproductive toxicant, male reproductive toxicant, developmental toxicant, essential medicine

World Health Organisation international non-proprietary name

paclitaxel

Connected on Wikidata

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