(2R)-daptomycin

Details

Instance of

type of chemical entity

Subclass of

lipopeptide, biogenic cyclopeptide

active ingredient in

Cubicin

canonical SMILES

CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C

chemical formula

C₇₂H₁₀₁N₁₇O₂₆

defined daily dose

0.28

found in taxon

Streptomyces filamentosus

has characteristic

biopharmaceutical

has use

medication

isomeric SMILES

CCCCCCCCCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]3[C@@H](C)OC(=O)[C@H](CC(=O)C4=C(N)C=CC=C4)NC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN)NC(=O)CNC3=O)[C@H](C)CC(O)=O

manufacturer

Pfizer

mass

1619.710366

medical condition treated

staphylococcal infection, infective endocarditis, bacterial infectious disease, cellulitis, septic arthritis, skin infection, staphylococcus aureus septicemia, bacterial infectious disease

pregnancy category

US pregnancy category B

significant drug interaction

rosuvastatin, simvastatin, atorvastatin, fluvastatin, pravastatin, rosuvastatin, simvastatin, atorvastatin, fluvastatin, pravastatin

stereoisomer of

decanoyl-Trp-Asn-Asp-Thr(1)-Gly-Orn-Asp-D-Ala-Asp-Gly-D-Ser-Glu(3S-Me)-Asp(Ph(2-NH2))-(1), (2S)-daptomycin

stylized name

DAPTOmycin

subject has role

antibiotic, bactericide

WHO Aware Classification

reserve

World Health Organisation international non-proprietary name

daptomycin

Authority files