3-hydroxy-3-methylglutaryl-CoA reductase

Details

Instance of

protein

Part of

Hydroxymethylglutaryl-CoA reductase, metazoan, Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily, Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily, Hydroxymethylglutaryl-CoA reductase, N-terminal, Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily, Eukaryotic Sterol Transporter, Sterol-sensing domain, protein family, Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

Has parts

Sterol-sensing domain, Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

biological process

visual learning, steroid metabolic process, sterol biosynthetic process, negative regulation of striated muscle cell apoptotic process, coenzyme A metabolic process, response to nutrient, positive regulation of skeletal muscle tissue development, lipid metabolism, positive regulation of cardiac muscle cell apoptotic process, negative regulation of insulin secretion involved in cellular response to glucose stimulus, ageing, negative regulation of apoptotic process

cell component

integral component of membrane, endoplasmic reticulum membrane, membrane, intracellular membrane-bounded organelle, peroxisomal membrane, endoplasmic reticulum, peroxisomal membrane, endoplasmic reticulum membrane

EC enzyme number

1.1.1.34

encoded by

HMGCR

found in taxon

Homo sapiens

molecular function

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein homodimerization activity, hydroxymethylglutaryl-CoA reductase (NADPH) activity, protein binding, NADP binding, NADPH binding, oxidoreductase activity, protein phosphatase 2A binding

physically interacts with

atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, pravastatin, rosuvastatin, simvastatin