topiramate

Details

Instance of

type of chemical entity

Subclass of

2,2,7,7-tetramethyltetrahydro-2H,3aH,7H-bis[1,3]dioxolo[4,5-b:4′,5′-d]pyran-3a-yl)methyl sulfamate

active ingredient in

Trokendi, Qudexy, Topamax, Topiragen

canonical SMILES

CC1(OC2COC3(C(C2O1)OC(O3)(C)C)COS(=O)(=O)N)C

chemical formula

C₁₂H₂₁NO₈S

defined daily dose

0.3

has characteristic

bitterness

has use

medication

isomeric SMILES

CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C

legal status (medicine)

boxed warning

mass

339.099

medical condition treated

bipolar disorder, focal epilepsy, infantile epileptic encephalopathy, tonic–clonic seizure, pain, mood disorder, migraine, post-traumatic stress disorder, migraine with aura, epilepsy, intracranial hypertension, essential tremor

physically interacts with

Carbonic anhydrase 1, Carbonic anhydrase 12, Carbonic anhydrase 4, Carbonic anhydrase 7, Gamma-aminobutyric acid type A receptor subunit beta2, Gamma-aminobutyric acid type A receptor subunit gamma2, Sodium voltage-gated channel alpha subunit 10, Gamma-aminobutyric acid type A receptor subunit beta3, Sodium voltage-gated channel alpha subunit 5, Sodium voltage-gated channel alpha subunit 3, Gamma-aminobutyric acid type A receptor subunit delta, Sodium voltage-gated channel alpha subunit 11

pregnancy category

Australian pregnancy category D, US pregnancy category D

subject has role

neuroprotective agent, anti-obesity medication, anticonvulsant agent, carbonic anhydrase inhibitor, developmental toxicant

World Health Organisation international non-proprietary name

topiramate

Connected on Wikidata

Authority files