posaconazole

Details

Instance of

type of chemical entity

Subclass of

azole, 4-[4-[4-[4-[[(5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

active ingredient in

Noxafil, Posaconazole Sp

canonical SMILES

CCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F

chemical formula

C₃₇H₄₂F₂N₈O₄

has use

medication

isomeric SMILES

CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F

LiverTox likelihood score

LiverTox toxicity likelihood category E*

mass

700.329708

medical condition treated

aspergillosis

pregnancy category

Australian pregnancy category B3, US pregnancy category C

significant drug interaction

domperidone, ergotamine, ritonavir, panobinostat, tolterodine, famotidine, alfentanil, vardenafil, sunitinib, ranolazine, lapatinib, nilotinib

subject has role

antifungal, trypanocidal agent, 14-alpha demethylase inhibitor, bactericide

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