methotrexate

Details

Instance of

type of chemical entity

Subclass of

Amethopterin

Part of

cellular response to methotrexate, methotrexate transmembrane transporter activity, response to methotrexate

active ingredient in

Nordimet, Rheumatrex, Trexall, Xatmep, Otrexup, Rasuvo

canonical SMILES

CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

chemical formula

C₂₀H₂₂N₈O₅

defined daily dose

2.5

found in taxon

Gambierdiscus, Asimina triloba, Quambalaria cyanescens, Dolichousnea longissima

has use

medication

isomeric SMILES

CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

legal status (medicine)

boxed warning

manufacturer

Pfizer

mass

454.171

medical condition treated

head and neck cancer, spindle cell sarcoma, breast cancer, trophoblastic neoplasm, esophageal cancer, rheumatoid arthritis, juvenile rheumatoid arthritis, osteosarcoma, mycosis fungoides, lung benign neoplasm, testicular cancer, leukemia

physically interacts with

solute carrier family 46 member 1, solute carrier family 19 member 1

pregnancy category

Australian pregnancy category D, US pregnancy category X

route of administration

oral administration, intravenous infusion and defusion, intramuscular injection, intrathecal administration

significant drug interaction

nabumetone, naproxen, Diclofenac, piroxicam, (RS)-fenoprofen, (RS)-ketoprofen, (RS)-etodolac, tenoxicam, (±)-flurbiprofen, ibuprofen, indomethacin, sulindac

stereoisomer of

(R)-methotrexate

subject has role

folic acid, disease-modifying antirheumatic drug, enzyme inhibitor, Abortifacient Agents, Nonsteroidal, antineoplastic antimetabolite, dermatologic drug, folic acid antagonists, immunosuppressive drug, DNA polymerase inhibitors, essential medicine, developmental toxicant

World Health Organisation international non-proprietary name

methotrexate

Connected on Wikidata

Authority files