Prostaglandin-endoperoxide synthase 2

Details

Instance of

protein

Part of

Prostaglandin G/H synthase 2, Haem peroxidase domain superfamily, animal type, Haem peroxidase superfamily, EGF-like domain, protein family

Has parts

EGF-like domain

biological process

response to fructose, learning, response to organic substance, lipoxygenase pathway, cellular response to mechanical stimulus, response to manganese ion, angiogenesis, cellular response to hypoxia, embryo implantation, negative regulation of cell population proliferation, response to cytokine, negative regulation of smooth muscle contraction

cell component

cytoplasm, endoplasmic reticulum lumen, membrane, caveola, neuron projection, organelle membrane, endoplasmic reticulum, intracellular membrane-bounded organelle, endoplasmic reticulum membrane, protein-containing complex

EC enzyme number

1.14.99.1

encoded by

PTGS2

found in taxon

Homo sapiens

molecular function

arachidonate 15-lipoxygenase activity, metal ion binding, heme binding, enzyme binding, oxidoreductase activity, protein homodimerization activity, dioxygenase activity, protein binding, peroxidase activity, prostaglandin-endoperoxide synthase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, peroxidase activity

physically interacts with

aspirin, benzquinamide, carprofen, celecoxib, Diclofenac, (RS)-etodolac, etoricoxib, (±)-flurbiprofen, ibuprofen, (RS)-ketoprofen, ketorolac, lumiracoxib

Authority files