bromocriptine

Details

Instance of

type of chemical entity

Subclass of

ergoline alkaloid, biogenic 2,5-diketopiperazine

Has parts

nitrogen, carbon, bromine

active ingredient in

Cycloset, Parlodel

canonical SMILES

CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O

chemical formula

C₃₂H₄₀BrN₅O₅

defined daily dose

40

has use

medication

isomeric SMILES

CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O

LiverTox likelihood score

LiverTox toxicity likelihood category D

mass

653.221

medical condition treated

neuroleptic malignant syndrome, amenorrhea, acromegaly, Parkinson's disease, infertility, hyperprolactinemia, hypogonadism, prolactin producing pituitary tumor, prolactinoma

physically interacts with

5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 6, Adrenoceptor alpha 2A, Adrenoceptor alpha 2B, Adrenoceptor alpha 2C, Dopamine receptor D1, Dopamine receptor D2

pregnancy category

Australian pregnancy category A, US pregnancy category B

significant drug interaction

verapamil, lisinopril dihydrate, diltiazem, quinapril, ramipril, captopril, enalapril, trandolapril, fosinopril, perindopril, chlorthalidone, (RS)-sulpiride

stereoisomer of

LSM-5805, (5'alpha,8alpha)-2-Bromo-12'-hydroxy-5'-(2-methylpropyl)-3',6',18-trioxo-2'-(propan-2-yl)ergotaman

subject has role

dopamine agonist, antiparkinson, hormone antagonist

World Health Organisation international non-proprietary name

bromocriptine

Authority files