voriconazole

Details

Instance of

type of chemical entity

Subclass of

azole

active ingredient in

Vfend, Voriconazole Accord, Voriconazole Hospira

canonical SMILES

CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O

chemical formula

C₁₆H₁₄F₃N₅O

found in taxon

Dendrodochium

has use

medication

isomeric SMILES

C[C@@H](C1=NC=NC=C1F)[C@](O)(CN2C=NC=N2)C3=CC=C(F)C=C3F

LiverTox likelihood score

LiverTox toxicity likelihood category B

mass

349.115

medical condition treated

aspergillosis, fusariosis, candidiasis, systemic mycosis, lung disease, pneumonia, esophageal candidiasis

significant drug interaction

amiodarone, disopyramide, ranolazine, quinine, vandetanib, vardenafil, sunitinib, dasatinib monohydrate, lapatinib, sorafenib, nilotinib, panobinostat

stereoisomer of

(2R,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, ent-voriconazole, (2S,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1,2,4-triazol-1-yl)-2-butanol

subject has role

cytochrome P-450 CYP3A inhibitors, antifungal, 14-alpha demethylase inhibitor, essential medicine

World Health Organisation international non-proprietary name

voriconazole