ketoconazole

Details

Instance of

group of stereoisomers

Subclass of

azole

active ingredient in

Ketoconazole Hra

canonical SMILES

CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

chemical formula

C₂₆H₂₈Cl₂N₄O₄

defined daily dose

0.2, 0.4

found in taxon

Streptomyces hygroscopicus, Anomospermum grandifolium, Dendrodochium

has use

medication

legal status (medicine)

boxed warning

LiverTox likelihood score

LiverTox toxicity likelihood category A

mass

530.148761

MCN code

2934.99.31

medical condition treated

vulvovaginal candidiasis, oral candidiasis, coccidioidomycosis, leishmaniasis, dermatomycosis, chronic mucocutaneous candidiasis, paracoccidioidomycosis, blastomycosis, candidiasis, tinea, tinea pedis, histoplasmosis

physically interacts with

Potassium voltage-gated channel subfamily A member 10

pregnancy category

Australian pregnancy category B3, US pregnancy category C

significant drug interaction

domperidone, ergotamine, pimozide, buprenorphine, simvastatin, simvastatin, quetiapine, alfentanil, fluticasone, cyclosporine, cyclosporine, cyclosporine

subject has role

xenobiotic-transporting ATPase inhibitor, cytochrome P-450 CYP3A inhibitors, antifungal, 14-alpha demethylase inhibitor

World Health Organisation international non-proprietary name

ketoconazole

Authority files