hydroxycarbamide

Details

Instance of

type of chemical entity

Subclass of

carbamide

Part of

response to hydroxyurea, cellular response to hydroxyurea

active ingredient in

Siklos, Hydrea, Droxia

canonical SMILES

C(=O)(N)NO

chemical formula

CH₄N₂O₂

found in taxon

Streptomyces nigra

has use

medication

legal status (medicine)

boxed warning

LiverTox likelihood score

LiverTox toxicity likelihood category C

mass

76.027

medical condition treated

head and neck cancer, Bellini duct carcinoma, ovarian cancer, uterine cancer, non-small-cell lung carcinoma, acropustulosis, brain cancer, essential thrombocytosis, prostate cancer, melanoma, hypereosinophilic syndrome, polycythemia vera

physically interacts with

Ribonucleotide reductase catalytic subunit M1, Ribonucleotide reductase regulatory subunit M2, Ribonucleotide reductase catalytic subunit M1, Ribonucleotide reductase regulatory subunit M2, Ribonucleotide reductase regulatory TP53 inducible subunit M2B

pregnancy category

Australian pregnancy category D, US pregnancy category D

subject has role

enzyme inhibitor, DNA polymerase inhibitors, antineoplastic, antisickling agents, essential medicine, developmental toxicant

World Health Organisation international non-proprietary name

hydroxycarbamide

Authority files